Talk Title: Proteome Landscape of Hepatocellular Carcinoma
Ying Jiang is the professor from National Center for Protein Science (Beijing), State Key Laboratory of Proteomics, Beijing, China. Dr. Jiang is interested in liver proteomics. She is working on understanding the physiology of liver and the pathology of live diseases. Dr. Jiang participated in the international collaborative Human Liver Proteome Project (HLPP) and contributed to the construction of the first protein expression profile of human liver. Drawing on data from this research, she has developed Liverbase (http://liverbase.hupo.org.cn)— the searchable human liver proteome data— as a unique public resource for the life science research community. She also systematically investigated the differentially expressed proteins in the progress of liver diseases (such as adiposis hepatica, hepatitis, fibrosis, and hepatocellular carcinoma). Currently, she is working on personalized proteomic characterization of hepatocellular carcinomas for its further precision medicine.
Hepatocellular carcinoma (HCC) is a highly lethal cancer, ranking as the ﬁfth most prevalent tumor and the second leading cause of cancer-related deaths worldwide. In China, chronic infection with hepatitis B virus (HBV) is one of its major risk factors, most patients are diagnosed at advanced stages of HCC with poor survival. A comprehensive molecular view of cancer is necessary for understanding the underlying mechanisms of disease, improving prognosis, and ultimately guiding treatment. Here we performed a comprehensive mass-spectrometry-based proteomic characterization of HCC tumors and paired no tumor tissues. Based on protein profiling data, those HCC cases were stratified into three subtypes. Proteomic alterations in signature molecules/pathways and networks among subtypes were analyzed to decipher the molecular characteristics of HCC and contribute to new personalized treatment strategies.