Talk Title: Psoriatic arthritis through the omics lens
Vinod Chandran MBBS MD DM PhD, is a rheumatologist and clinician-scientist and an Associate Professor of Medicine & Laboratory Medicine and Pathobiology at the University of Toronto. He co-directs the Psoriatic Arthritis Program at the University Health Network. Dr. Chandran’s research interests lie in the genetic and molecular epidemiology of psoriasis and psoriatic arthritis, especially with regard to prognosis. His current translational research program is focused on developing proteomic and metabolomics-based screening and prognostic tools for psoriatic arthritis, a potentially debilitating inflammatory arthritis, as well as identifying and reducing barriers to multidisciplinary care of patients with psoriatic arthritis. He has published 144 journal articles, 2 books and 7 book chapters. His current research is supported by research grants from the Canadian Institutes of Health Research, Canadian Rheumatology Association, International League of Associations for Rheumatology, The Arthritis Foundation, and the Krembil Foundation.
Theme: Disease and Clinical Proteomics
Title: Psoriatic arthritis through the omics lens
Psoriatic arthritis is a unique inflammatory arthritis associated with skin psoriasis. In spite of better recognition of this condition and the advent of effective therapy, early diagnosis and disease stratification remain unmet needs in this heterogeneous disease. Genomic studies have led to better understanding of disease pathogenesis. Ongoing transcriptomic, proteomic and metabolomic studies will lead to identifying pathways associated with development of arthritis in patients with psoriasis and likely lead to identifying clinically actionable biomarkers as well as drug targets. My lecture will review the results of omics studies in psoriatic arthritis, the current understanding on disease pathogenesis, the current status of biomarker discovery, challenges faced, promising markers identified, and the way forward.