Ruedi Aebersold

Ruedi Aebersold

Talk Title: The Proteome in Context


Ruedi Aebersold is a Swiss and Canadian scientist trained at the Biocenter, University of Basel. He completed his education at Caltech. He is a Professor at ETH Zurich and the University of Zurich. He was on the faculties of the Universities of British Columbia and Washington and co-founded the Institute for Systems Biology in Seattle. He is on the SAB of a number of research organizations and has served as senior editor for Molecular and Cellular Proteomics and Molecular Systems Biology. He has co-founded several companies and holds several public service appointments.

The research focus of his group is the proteome. The group has pioneered several widely used techniques and generated a range of open access/open source software and statistical tools that have contributed to making proteomic research results transparent and accurate. The work has been recognized with numerous awards and prizes. More than 40 trainees of the group have reached faculty status at leading research institutions worldwide.

The Proteome in Context

Ruedi Aebersold,
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich and Faculty of Science, University of Zurich

Advances in discovery proteomics have made it possible to map the protein contents of cells to saturation, at least at the resolution of expressed loci. To gain new biological or clinical insights, to date, the thus identified proteins have been largely treated as independent entities. However, proteins generally function in context with other biomolecules in the form of macromolecular assemblies. To understand how the proteome as a whole controls, coordinates and catalyzes most biochemical functions of a cell, it is therefore essential to also determine its spatial and temporal organization.

In this presentation we will discuss emerging computational and quantitative proteomic techniques to determine the organization of the proteome and to extract functional information from the results. The ultimate goal of this work is to reach a comprehensive understanding how the proteome, considered as a complex system, reacts to genetic or external perturbations and thus determines cellular and organismic phenotypes.