hupo2017@conferencepartners.ie

Liquid Biopsy Workshop

 

A HUPO Workshop on Liquid Biopsy:

Principles, Process and Practices

Classroom E2.18, O’Brien Centre for Science, University College Dublin

Objective
In the era of personalized medicine, it is desirable to have noninvasive or minimally invasive methods to determine and follow longitudinally the molecular composition of a patient’s progress/health, which will help gain a broader molecular understanding of the disease. One such approach is through liquid biopsies that can be used to characterize the specific disease and monitor proteomic changes over time using repeat sampling of biofluids. While most of the research on liquid biopsies uses blood derivatives, other biofluids that can be used include urine, sputum, saliva, tears and nipple aspirate fluid. Liquid biopsies have the potential to help clinicians screen for disease, stratify patients to the best treatment, monitor treatment response and development of resistance. Liquid biopsies also offer an opportunity to detect diseases at the earliest stage and monitor recurrence in cases where biopsy is difficult, such as brain cancer. The race to capitalize on the approach has ignored the contribution of proteomics that is poised to benefit more broadly than genomics. The workshop will discuss the principles, process and practice of liquid biopsy in general and the role of proteomics in particular. Attendees will learn both existing and emerging technologies that can be beneficial in the pursuit of liquid biopsy in the point of care applications.

9:00 AM – 9:10 AM Welcome and Learning Objectives — Chris Sutton (University of Bradford, UK)
9:10 AM – 9:30 AM State-of-the-Science in Liquid Biopsy — Sudhir Srivastava (National Cancer Institute, US)
9:30 AM – 10:30 AM Biology, Technology and Discovery of Liquid Biopsy Approaches
Chair: Chris Sutton

Presenters:

• “The Beauty and the Beast, or the pros and cons of tear analysis”, Eva Csosz (University of Debrecen, Hungary)
• “Proteomic Characterization of Microneedle Extracted Human Dermal Interstitial Fluid”, Bao Tran (Excet Inc, US)
• “Saliva: a potential source of molecular signatures for metastasis in Oral Cancer”, Tatiane de Rossi (Brazilian Center for
Research in Energy and Materials, Brazil)
• “TBA”, Keiko Yamamoto (Niigata University, Japan)
• “Advantages and disadvantages of using nipple aspirate fluid for diagnosing breast health”, Chris Sutton (University of Bradford, UK)

10:30 AM – 11:00 AM Coffee Break
11: 00 AM – 12:00 AM Translation of Liquid Biopsy Towards Clinical Use
Chair: John Timms (University College London, UK)

Presenters:

• “Proteomics, Biomarkers and Liquid Biopsies: The Man Who Knew Too Little”, John Semmes (Eastern Virginia Medical School, US)
• “Developing Proteomic Liquid Biopsy”, Mark Baker (Macquarie University, Aus)
• “Translating the Shape of Asthma”, Paul Skipp (University of Southampton, UK)
• “From proximal brain fluids to blood biomarkers”, Linnea Lagerstedt (Centre Medical Universitaire, Switzerland)
• “The Power of Longitudinal Biomarker Analysis”, John Timms (University College London, UK)

12:00 AM – 12:45 AM Interactive Discussions
Moderator: John Semmes

Discussion Topics:

1. Circulating proteins, exosomes, microvesicles and other non-invasive analytes, e.g., metabolites
2. Biospecimen selection, procurement, and processing
3. Challenges and opportunities in translating liquid biopsy into clinics
4. Discovery Approaches

12:45 PM – 1:45 PM Lunch Break
1:45PM – 2:45 PM Public-Private Partnership: Collaborations with Industry, Academia and Government Sectors
Chair – Robert O’Connor (Irish Cancer Society, Ireland)

Presenters:

• “Innovative Medicines Initiative: An opportunity to engage with the Pharmaceutical Industry”, Ciaran Duffy (Enterprise Ireland,
Ireland)
• “The SOMAscan® Assay for Proteomic Profiling”, Sheri Wilcox (Somalogic Inc, US),
• “Stroma Liquid Biopsy – Biomarkers of the Dysregulation of the Serum Proteome in Cancer”, Matt Kuruc (Biotech Support Group Llc,
US)
• “An innovative alternative for targeted protein biomarker discovery in liquid biopsy applications”, Leonhard Pollack (Olink
Bioscience AB, Sweden)

2:45 P.M. – 3:45 PM Implementation of Liquid Biopsy into the Point of Care
Chair: Sudhir Srivastava

Presenters:

• “Exosomes vs whole plasma for liquid biopsy”, Sam Hanash (MD Anderson, US),
• “Implementation of Point-of-Care devices for liquid biopsy”, Dan Chan (John Hopkins Medicine, US),
• “Tumor associated autoantibodies in liquid biopsies”, Josh Labaer (Arizona State University, US),
• “Practical considerations for the implementation of liquid biopsies at the point of care for the management of arthritis”, Vinod
Chandran (University of Toronto, Canada)

3:45 AM – 4:00 AM Coffee Break
4:00 PM – 4.45 PM Interactive Discussions
Moderator: Sudhir Srivastava

Discussion Topics:
1. Opportunities in pre-competitive space among industry, academia and government
2. Challenges and opportunities in proteomics-based liquid biopsy in the point-of-care research
3. Regulatory requirements in implementing liquid biopsy
4. Harmonization and validation of liquid biopsy approaches for clinical use

4.45 PM – 5.00PM Summary

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Coaches to the Convention Centre Dublin

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