A HUPO Workshop on Liquid Biopsy:
Principles, Process and Practices
Classroom E2.18, O’Brien Centre for Science, University College Dublin
Objective
In the era of personalized medicine, it is desirable to have noninvasive or minimally invasive methods to determine and follow longitudinally the molecular composition of a patient’s progress/health, which will help gain a broader molecular understanding of the disease. One such approach is through liquid biopsies that can be used to characterize the specific disease and monitor proteomic changes over time using repeat sampling of biofluids. While most of the research on liquid biopsies uses blood derivatives, other biofluids that can be used include urine, sputum, saliva, tears and nipple aspirate fluid. Liquid biopsies have the potential to help clinicians screen for disease, stratify patients to the best treatment, monitor treatment response and development of resistance. Liquid biopsies also offer an opportunity to detect diseases at the earliest stage and monitor recurrence in cases where biopsy is difficult, such as brain cancer. The race to capitalize on the approach has ignored the contribution of proteomics that is poised to benefit more broadly than genomics. The workshop will discuss the principles, process and practice of liquid biopsy in general and the role of proteomics in particular. Attendees will learn both existing and emerging technologies that can be beneficial in the pursuit of liquid biopsy in the point of care applications.
9:00 AM – 9:10 AM | Welcome and Learning Objectives — Chris Sutton (University of Bradford, UK) |
9:10 AM – 9:30 AM | State-of-the-Science in Liquid Biopsy — Sudhir Srivastava (National Cancer Institute, US) |
9:30 AM – 10:30 AM | Biology, Technology and Discovery of Liquid Biopsy Approaches Chair: Chris Sutton Presenters: • “The Beauty and the Beast, or the pros and cons of tear analysis”, Eva Csosz (University of Debrecen, Hungary) |
10:30 AM – 11:00 AM | Coffee Break |
11: 00 AM – 12:00 AM | Translation of Liquid Biopsy Towards Clinical Use Chair: John Timms (University College London, UK) Presenters: • “Proteomics, Biomarkers and Liquid Biopsies: The Man Who Knew Too Little”, John Semmes (Eastern Virginia Medical School, US) |
12:00 AM – 12:45 AM | Interactive Discussions Moderator: John Semmes Discussion Topics: 1. Circulating proteins, exosomes, microvesicles and other non-invasive analytes, e.g., metabolites |
12:45 PM – 1:45 PM | Lunch Break |
1:45PM – 2:45 PM | Public-Private Partnership: Collaborations with Industry, Academia and Government Sectors Chair – Robert O’Connor (Irish Cancer Society, Ireland) Presenters: • “Innovative Medicines Initiative: An opportunity to engage with the Pharmaceutical Industry”, Ciaran Duffy (Enterprise Ireland, |
2:45 P.M. – 3:45 PM | Implementation of Liquid Biopsy into the Point of Care Chair: Sudhir Srivastava Presenters: • “Exosomes vs whole plasma for liquid biopsy”, Sam Hanash (MD Anderson, US), |
3:45 AM – 4:00 AM | Coffee Break |
4:00 PM – 4.45 PM | Interactive Discussions Moderator: Sudhir Srivastava Discussion Topics: |
4.45 PM – 5.00PM | Summary
/td> |
Coaches to the Convention Centre Dublin
<