Talk Title: Viral infection-driven dynamics of proteome organization
Ileana Cristea is a Professor at Princeton University, where her laboratory investigates mechanisms of cellular defense against viral pathogens to discover targets for antiviral therapies. She has promoted the integration of virology with proteomics, and has developed methods for studying virus-host protein interactions in space and time during infection. This has allowed her group to bridge developments in mass spectrometry to important findings in virology. For example, her laboratory has contributed to the emergence of the research field of nuclear DNA sensing in immune response, and has discovered sirtuins as broad-spectrum antiviral factors. Dr. Cristea is President-Elect of US HUPO, co-chair of Infectious Disease Initiative of HUPO, and has taught the summer Proteomics Course at Cold Spring Harbor Laboratory for over ten years. She was recognized with awards from NIH/NIDA Avant-Garde Award (2008), HFSP (2009), ACS (2011), ASMS (2012), the Molecular Cellular Proteomics Lectureship (2013), and the Mallinckrodt Foundation (2015).
Viral infection-driven dynamics of proteome organization
Ileana M. Cristea
Department of Molecular Biology, Princeton University, Princeton, NJ 08540, U.S.A.
The coexistence and coevolution of hosts with pathogens is intrinsic to our ecosystem. Pathogenic infections induce an array of changes in the hosts that are tightly linked to the progression of infection and establishment of disease. At the cellular level, this is reflected in alterations in host cell composition, organization, and ability to communicate with other cells. Thus, changes in the host proteome, metabolome, lipidome, and secretome have started to be recognized as signatures of infectious or disease states. These alterations function to either induce host defenses that counteract the infection or promote pathogen replication for spread of infection. Consequently, the discovery and characterization of these signature changes are essential for both understanding the biology of infection and identifying novel targets for therapeutic interventions. This presentation will highlight the value of advanced mass spectrometry-based proteomics for defining the dynamics of proteome organization and understanding cellular defense mechanisms during viral infections.