H. Alexander Ebhardt, Ph.D.
Dr. Ebhardt received his Ph.D. from Simon Fraser University, Burnaby, B.C., Canada characterizing small RNAs in virally infected plants. During his post-doctoral research he developed a method to rapidly quantify activity of peptidyl transferases using MALDI-ToF MS in combination with stable isotope labelling of substrate and product peptides. Peptidyl transferases also generate peptides flanked by basic amino acids generating precursors with sequestered protons on either termini resulting in complete b- and y-ion fragment ion series per MS/MS spectrum in ESI-mode. Dr. Ebhardt was instrumental in the first proteome wide association study (PWAS) in animals using SWATH-MS. Recently he became junior group leader in Systems Biology Ireland where he characterizes perturbed cellular systems using high mass accuracy mass spectrometers.