hupo2017@conferencepartners.ie

Dr. Andrew Percy

Dr. Andrew Percy

Cambridge Isotope Laboratories, Inc.

Talk Title: Standardizing MS ‘Omics for Precise and Accurate Qualification/Quantification

Bio:

Dr. Andrew Percy is the Senior Applications Chemist for Mass Spectrometry at Cambridge Isotope Laboratories, Inc. (CIL). Andrew received his MSc and PhD degrees from the University of Calgary (Alberta, Canada) in the disciplines of analytical and bioanalytical chemistry. After a brief postdoctoral fellowship in 2011, he served as the Quantitative Proteomics group leader at the UVic-Genome BC Proteomics Centre (British Columbia, Canada), where his research focused on the development and application of novel technologies for the targeted and multiplexed quantitation of proteins in various biological samples. Andrew’s position at CIL harnesses his expertise with MS and isotopically labeled analytes. He is involved with the development, management, and assessment of various stable isotope-labeled products and their applications to qualitative/quantitative MS ‘omics.

Abstract:

LC-MS technology and its associated ‘omics methodologies have advanced considerably over the past several years toward improved analyte qualification and quantification. Considering the expanding and continued goals of ‘omics researchers, the need for robust tools to assess workflow performance and improve assay development remains essential. This talk aims to provide an overview of new sets of stable isotope-labeled mixtures for metabolomic- or proteomic-centered applications. These collectively afford unique analytical benefits that should help streamline method optimization, system suitability, and quantitative performance in MS ‘omics studies. Aspects of their development and application in basic research and clinical translation studies will be presented. Their utility will be highlighted against a few different sample matrices that were prepared and processed using a number of methodologies, LC-MS platforms, and analysis strategies.